Anticancer agent 108

Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor with significant antitumor activity and less toxicity to normal and pseudonormal cells. Anticancer agent 108 (Compound 3.10) had no acute toxic effect on С57BL/6 mice[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-108.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C(C3=C(C(C4=C(C(O)=CC=C4)C3=O)=O)S2)C5=CC=CO5)S1

Molecular Formula

C18H9NO5S2

Molecular Weight

383.40

References & Citations

[1]Ivasechko I, et al. Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone) . Eur J Med Chem. 2023 Apr 5;252:115304.