22- (4?-py) -JA

Product Specifications

CAS Number

1178895-15-2

Target

Akt|||mTOR

Related Pathways

Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling

Bioactivity

22- (4?-py) -JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting the AKT/mTOR/p70S6K signaling pathway. It also impedes tumor cell invasion and angiogenesis in human umbilical vein endothelial cells (HUVEC), while suppressing the expression of metalloproteinases (MMP-2 and MMP-9), hypoxia-inducible factor 1? (HIF-1?), and vascular endothelial growth factor (VEGF) . Its potent anticancer activity is particularly noted against non-small cell lung cancer (NSCLC) [1].

Smiles

C(OC(=O)C=1C=CN=CC1)[C@@H]2N3[C@]([C@]4(C5=C(C[C@@]([C@@H]3C#N)(N4C)[H])C(=O)C(C)=C(OC)C5=O)[H])(CC6=C2C(=O)C(OC)=C(C)C6=O)[H]

Molecular Formula

C32H30N4O8

Molecular Weight

598.6

Shipping Conditions

Cool pack

Storage Temperature

-20°C