Cavα2δ1&NET-IN-2
Product Specifications
UNSPSC Description
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1].
Target Antigen
Calcium Channel; Monoamine Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cavα2δ1-net-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCN(C2=NC(N)=NC=C21)C)C3=CC(O[C@H](C4=CC=CS4)CCNC)=CC=C3
Molecular Weight
438.55
References & Citations
[1]Díaz JL, et al. Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter. J Med Chem. 2021 Feb 25;64(4):2167-2185.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148863/Cavα2δ1-NET-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148863/
Clinical Information
No Development Reported
CAS Number
2143586-17-6
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