P2X7 receptor antagonist-3
P2X7 receptor antagonist-3 is a potent P2X7 receptor antagonist with P2X7R IC50 values of 4.2 nM in humans and 6.8 nM in rats[1].
Product Specifications
CAS Number
1627900-92-8
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p2x7-receptor-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=C(CC1)N(C3=NC=CC=N3)N=N2)C4=CC=CC(C(F)(F)F)=C4Cl
Molecular Formula
C17H12ClF3N6O
Molecular Weight
408.76
References & Citations
[1]Brad M Savall, et al. Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists. ACS Med Chem Lett. 2015 Apr 24;6 (6) :671-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
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