L-I-OddU
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis[1][2].
Product Specifications
CAS Number
207920-87-4
UNSPSC
12352005
Target
DNA/RNA Synthesis; EBV; Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/l-i-oddu.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1O[C@H](N(C=C(C(N2)=O)I)C2=O)CO1
Molecular Formula
C8H9IN2O5
Molecular Weight
340.07
References & Citations
[1]Kira T, et, al. Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase. Antimicrob Agents Chemother. 2000 Dec;44 (12) :3278-84.|[2]Focher F, et, al. Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development. Curr Drug Targets Infect Disord. 2003 Mar;3 (1) :41-53.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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