Topoisomerase II inhibitor 11

Topoisomerase II inhibitor 11 (compound 3d) is a potent Topoisomerase II inhibitor, with an IC50 of 2.89 μM. Topoisomerase II inhibitor 11 shows 92.46% inhibition on renal cancer cell line A498 with an IC50 of 3.5 μM. Topoisomerase II inhibitor 11 causes cell cycle arrest at the G2/M phase leading to cell proliferation inhibition and pro-apoptotic activity[1].

Product Specifications

CAS Number

[2476559-00-7]

UNSPSC

12352005

Target

Apoptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-ii-inhibitor-11.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C2=CC=CC=C2)N=C(SC=C3C4=CC=C(Cl)C=C4)N3C1C5=CC=C(Cl)C=C5)OCC.[H]Br

Molecular Formula

C27H21BrCl2N2O2S

Molecular Weight

588.34

References & Citations

[1]Nemr MTM, et al. New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study. Bioorg Chem. 2020 Oct;103:104134.