C-Met-IN-10
C-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].
Product Specifications
CAS Number
2415291-03-9
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NN(C(N(C1=O)C)=O)C2=CC=CC=C2)NC3=CC=C(C(F)=C3)OC4=CC(NC(C5CC5)=O)=NC=C4
Molecular Formula
C26H21FN6O5
Molecular Weight
516.48
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Polyclonal Antibody to Extracellular Signal Regulated Kinase 1 (ERK1)