IRAK4-IN-15

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 μM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

Product Specifications

CAS Number

2667681-85-6

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irak4-in-15.html

Solubility

10 mM in DMSO

Smiles

CC1=NC=C(C2=NC3=C(NC(C)C)N=C(NC4=CN(C(C5)CC65CN(C)C6)N=C4)N=C3C=C2F)C=N1

Molecular Formula

C25H29FN10

Molecular Weight

488.56

References & Citations

[1]Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115815.