Amotosalen

Amotosalen (S-59 (free base) ) is a light-activated, DNA and RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD) [1][2].

Product Specifications

CAS Number

[161262-29-9]

Product Name Alternative

S-59 (free base)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/amotosalen.html

Smiles

O=C1OC2=C(C)C(OC(C)=C3COCCN)=C3C=C2C(C)=C1

Molecular Formula

C17H19NO4

Molecular Weight

301.34

References & Citations

[1]Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17 (1) :66-8.|[2]Lanteri MC, et al. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion. 2020 Jun;60 (6) :1319-1331.