cis,trans-Germacrone
Product Specifications
UNSPSC Description
cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].
Target Antigen
Akt; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis;PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cis-trans-germacrone.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C1C(C/C(C)=C\CC/C(C)=C/C\1)=O
Molecular Weight
218.33
References & Citations
[1]Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23(6):452.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145670/cis-trans-Germacrone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145670/
Clinical Information
No Development Reported
CAS Number
32663-51-7
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