HDMAPP (triammonium)
HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E) -HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α) [1].
Product Specifications
CAS Number
[443892-56-6]
UNSPSC
12352211
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdmapp-triammonium.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
OC/C(C)=C/COP(OP(O)(O)=O)(O)=O.N.N.N
Molecular Formula
C5H21N3O8P2
Molecular Weight
313.18
References & Citations
[1]Boëdec A, et al. Synthesis and biological activity of phosphonate analogues and geometric isomers of the highly potent phosphoantigen (E) -1-hydroxy-2-methylbut-2-enyl 4-diphosphate. J Med Chem. 2008 Mar 27;51 (6) :1747-54.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF1A/CD120a
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