BI-882370
BI-882370 is a potent and selective RAF kinase inhibitor with low nanomolar IC50 values against oncogenic BRAF (V600E), wild-type BRAF, and CRAF. It also exhibits activity against SRC family kinases. This inhibitor is a valuable research tool for studying MAPK pathway signaling in cancers, supporting both in vitro and in vivo preclinical investigations.
Product Specifications
CAS Number
1392429-79-6
Product Name Alternative
C-Raf, B-Raf (V600E), B-Raf, BI882370, BI-882370, BI 882370, inhibit, Inhibitor, Raf kinases, Raf
Field of Research
Signal Transduction
Purity
97.33% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.76 mM) ; DMSO:5 mg/mL (8.78 mM)
Smiles
CCCS (=O) (=O) Nc1ccc (F) c (c1F) -n1cc (-c2cncnc2) c2nc (ccc12) N (C) C1CCN (CC) CC1
Molecular Formula
C28H33F2N7O2S
Molecular Weight
569.67
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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