GluN2B receptor modulator-1
GluN2B receptor modulator-1 is a selective GluN2B negative allosteric modulator with an IC50 value of 31 nM.
Product Specifications
CAS Number
2222010-71-9
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glun2b-receptor-modulator-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)C2=C(N1CC(N3CCC3)=O)C=C(C4=CC=C(C(F)(F)F)S4)C=N2
Molecular Formula
C17H15F3N4O2S
Molecular Weight
396.39
References & Citations
[1]Chrovian CC, et al. Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6- (5-thiophenyl) -1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders. J Med Chem. 2020 Sep 10;63 (17) :9181-9196.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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