Tri (TLR4-IN-C34-C2-amide-C3-amide-PEG1) -amide-C3-COOH

Tri (TLR4-IN-C34-C2-amide-C3-amide-PEG1) -amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].

Product Specifications

CAS Number

[1637413-46-7]

UNSPSC

12352005

Target

PROTAC Linkers; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tri-tlr4-in-c34-c2-amide-c3-amide-peg1-amide-c3-cooh.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCC(NC(COCCC(NCCCNC(CCCCO[C@H]1[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O1)=O)=O)(COCCC(NCCCNC(CCCCO[C@H]2[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2)=O)=O)COCCC(NCCCNC(CCCCO[C@H]3[C@H](NC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O3)=O)=O)=O

Molecular Formula

C84H134N10O39

Molecular Weight

1908.01

References & Citations

[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013;8 (6) :e65779. Published 2013 Jun 12.