BACE1-IN-8
BACE1-IN-8 (compound 70b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 3.9 µM[1].
Product Specifications
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-8.html
Solubility
10 mM in DMSO
Smiles
CCC[C@@H]1NC([C@@H](NC([C@@H](N)CCC(O)=O)=O)C(OC/C=C\C[C@@H]([C@H](O)CNC2=CC=C(C)C=C2)NC1=O)(C)C)=O
Molecular Formula
C29H45N5O7
Molecular Weight
575.70
References & Citations
[1]Otani T, Hattori Y, Akaji K, Kobayashi K. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorg Med Chem. 2021 Dec 15;52:116517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
Frequently Asked Questions
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