PD-1/PD-L1-IN-17
PD-1/PD-L1-IN-17 (Compound P20) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 26.8 nM. PD-1/PD-L1-IN-17 is a promising lead compound for the development of inhibitors of the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-17 has the potential for the research of cancer diseases[1].
Product Specifications
CAS Number
2851938-36-6
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd-1-pd-l1-in-17.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H](CO)NCC1=CC2=C(ON=C2NC3=CC=CC(C4=CC=CC=C4)=C3Cl)C=C1)O
Molecular Formula
C23H20ClN3O4
Molecular Weight
437.88
References & Citations
[1]Huang X, et al. Design, synthesis, and structure-activity relationship of PD-1/PD-L1 inhibitors with a benzo[d]isoxazole scaffold. Bioorg Med Chem Lett. 2021 Nov 15;52:128403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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