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AAK1-IN-2 (TFA)

AAK1-IN-2 TFA (compound (S) -31) is a potent, selective and brain-penetrant inhibitor of Adaptor Protein 2-Associated Kinase 1 (AAK1), with an IC50 of 5.8 nM. AAK1-IN-2 TFA can be used for the research of neuropathic pain[1].

Product Specifications

CAS Number

2761587-28-2

UNSPSC

12352005

Target

AAK1

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aak1-in-2-tfa.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC([C@@H](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Molecular Formula

C24H22F6N4O4

Molecular Weight

544.45

References & Citations

[1]Hartz RA, et, al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65 (5) :4121-4155.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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