HCAII-IN-6

HCAII-IN-6 (Compound S-13) is a potent human carbonic anhydrase II (hCA II) inhibitor with a Ki of 4.4 nM. hCAII-IN-6 also inhibits other hCAs isoforms I, IV and IX, with Ki values of 9.2 nM, 480.2 nM and 14.7 nM, respectively. hCAII-IN-6 can be used for glaucoma research[1].

Product Specifications

CAS Number

[3067465-38-4]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/hcaii-in-6.html

Solubility

10 mM in DMSO

Smiles

NS(=O)(C1=CC=C(C=C1)C(N2CCN(C[C@@H]2CCO)CC3=CC=CC=C3)=O)=O

Molecular Formula

C20H25N3O4S

Molecular Weight

403.50

References & Citations

[1]Niccolò Chiaramonte, et al. 2- (2-Hydroxyethyl) piperazine derivatives as potent human carbonic anhydrase inhibitors: Synthesis, enzyme inhibition, computational studies and antiglaucoma activity. Eur J Med Chem. 2022 Jan 15;228:114026.