HGGPPS-IN-3
HGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS) . hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) . hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Product Specifications
CAS Number
[2763223-96-5]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hggpps-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(C2=NC3=C(C(NC(P(O)(O)=O)P(O)(O)=O)=N2)C=CS3)=CC=C1)NC4=CC(Br)=C(C=C4)C
Molecular Formula
C21H19BrN4O7P2S
Molecular Weight
613.31
References & Citations
[1]Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65 (3) :2471-2496.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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