Recombinant Human DR6/TNFRSF21 Protein (Fc Tag)
Product Specifications
Background
Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) . DR6 is also expressed on the tumor cell lines and can be induced by TNF-α.
Abbreviation
DR6; TNFRSF21
Synonyms
CD358; DR6; Death Receptor 6; TNFRSF21; Tumor Necrosis Factor Receptor Superfamily Member 21
UniProt
O75509
Accession Number
O75509
Expression System
HEK293 Cells
Tag
C-Fc
Sequence
Gln42-Leu350
Field of Research
Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/o8ckr8
Product MSDS
https://789.bio/eb/KS8S8K
Calculated Molecular Weight
61.7 kDa
Observed Molecular Weight
80-90 kDa
Species
Human
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
