MRGPRX1 agonist 2
MRGPRX1 agonist 2 (compound 1a) is a potent Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.48 μM. MRGPRX1 agonist 2 can be used for researching neuropathic pain[1].
Product Specifications
CAS Number
302952-43-8
UNSPSC
12352005
Target
Mas-related G-protein-coupled Receptor (MRGPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrgprx1-agonist-2.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=CC=C1OC2=C(C(C)=C(C)S3)C3=NC=N2
Molecular Formula
C15H14N2OS
Molecular Weight
270.35
References & Citations
[1]Berhane I, et al. Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1) . J Med Chem. 2022;65 (4) :3218-3228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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