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Crotonaldehyde Antibody: ATTO 488

Mouse Anti-Crotonaldehyde Monoclonal IgG1

Product Specifications

Background

Lipid peroxidation occurs when oxidizing agents attack carbon-carbon double bonds found in unsaturated lipids. In addition to membrane degradation, oxidation end-products have been found to damage cell viability through their mutagenic and toxic properties. These downstream functional consequences facilitate the development of disease and premature aging. Crotonaldehyde (CRA) is a carcinogenic, conjugated aldehyde produced endogenously via lipid peroxidation. It covalently modifies biomolecules, forming adducts with DNA and nucleophilic amino acid residues of proteins such as lysine (1).

Specifications

Specific for Crotonaldehyde modified proteins. Does not cross-react with Acrolein, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylglyoxal modified proteins.

Product Name Alternative

Crotonaldehyde Antibody, Croton aldehyde Antibody, Crotonaldehyde (CRA) Antibody, CRA Antibody, Crotonaldehyde conjugated protein antibody, Crotonaldehyde modified protein antibody, Crotonaldehyde-conjugated protein antibody, Crotonaldehyde-modified protein antibody, CRA-lysine adduct Antibody, Crotonaldehyde-lysine adduct Antibody

Synonyms

Crotonaldehyde Antibody, Clone 2A8.1: ATTO 488

UNSPSC

12352203

Host

Mouse

Species Reactivity

Species Independent

Immunogen

Crotonaldehyde modified Keyhole Limpet Hemocyanin (KLH)

Target

Crotonaldehyde

Clonality

Monoclonal

Isotype

IgG1

Clone

2A8.1

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Protein G Purified

Limit Of Detection

A 1:1000 dilution of SMC-534 was sufficient for detection of Crotonaldehyde-modified proteins in 1 µg of Crotonaldehyde-BSA conjugate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Concentration

1 mg/ml

Dilution

WB (1:1000); ELISA (1:1000); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Ichihashi, K. et al. (2001) J Biol Chem. 276, 23903-23913.

Product Datasheet

https://cdn.gentaur.com/products/400/4293597/datasheet/smc-534d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4293597/msds/smc-534d-a488.pdf

CAS Number

9007-83-4

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