GSK-3β inhibitor 7
Product Specifications
UNSPSC Description
GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder[1].
Target Antigen
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-7.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C=C1)S(=O)(N2C=C(C3=CC(Br)=CC=C32)C4=NC(NC5=C(C=CC=C5C)C)=NC=C4)=O
Molecular Weight
547.47
References & Citations
[1]Shuwen Han, et al. Structure-Based design of Marine-derived Meridianin C derivatives as glycogen synthase kinase 3β inhibitors with improved oral bioavailability: From aminopyrimidyl-indoles to the sulfonyl analogues. Bioorg Chem. 2022 Feb;119:105537.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143261/GSK-3β-inhibitor-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143261/
Clinical Information
No Development Reported
Curated Selection
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