GNMT (NM_018960) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. This protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia) . Alternative splicing results in multiple transcript variants. Naturally occurring readthrough transcription occurs between the upstream CNPY3 (canopy FGF signaling regulator 3) gene and this gene and is represented with GeneID:107080644. [provided by RefSeq, Jan 2016]
Synonyms
HEL-S-182mP
Gene ID
27232
UniProt
Q14749, V9HW60
Accession Number mRNA
NM_018960
Chromosomal Location
6p21.1
Expression System
HEK293T
Tag
C-Myc/DDK
Related Pathways
Glycine, serine and threonine metabolism
Field of Research
Glycine, serine and threonine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
32.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GNMT
Species
Human
Protein ID
NP_061833
Overview
Recombinant protein of human glycine N-methyltransferase (GNMT)
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/27232
Uniprot URL
https://www.uniprot.org/uniprot/Q14749
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018960
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_061833
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