B-Raf IN 6

B-Raf IN 6 (compound 2c) is a potent inhibitor of protein kinase B-Raf with an IC50 of 1.7 nM. B-Raf IN 6 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].

Product Specifications

CAS Number

[2648698-34-2]

UNSPSC

12352005

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/b-raf-in-6.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC(F)=CC=C1F)(NC2=CC=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCCC5)=N3)=C2F)=O

Molecular Formula

C24H21F3N6O2S2

Molecular Weight

546.59

References & Citations

[1]Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65 (2) :1552-1566.