Quinacrine (hydrochloride hydrate)

Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis[1].

Product Specifications

CAS Number

[6151-30-0]

Product Name Alternative

Mepacrine (hydrochloride hydrate) ; SN-390 (hydrochloride hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Mitophagy; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/quinacrine-hydrochloride-hydrate.html

Purity

98.18

Solubility

10 mM in DMSO

Smiles

CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.[H]Cl.[H]Cl.[H]O[H].[H]O[H]

Molecular Formula

C23H36Cl3N3O3

Molecular Weight

508.91

Precautions

H302, H315, H319, H335

References & Citations

[1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73 (1-2) :52-64.|[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.