Recombinant Human FKBP3/FKBP25 Protein (His Tag)

FKBP25 contains 1 PPIase FKBP-type domain; belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin; as well as histone deacetylases; the transcription factor YY1; casein kinase II; and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

25 kDa FK506-binding protein;25 kDa FKBP; FK506-binding protein 3; FKBP-25; FKBP-3; FKBP25; Immunophilin FKBP25; PPIase FKBP3; Peptidyl-prolyl cis-trans isomerase FKBP3; Rapamycin-selective 25 kDa immunophilin; Rotamase