Phosphoramide mustard
Phosphoramide mustard is a biologically active metabolite of Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard induces DNA damage[1][2].
Product Specifications
CAS Number
10159-53-2
UNSPSC
12352211
Hazard Statement
H301-H311-H331-H341
Target
DNA Alkylator/Crosslinker; Drug Metabolite
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phosphoramide-mustard.html
Solubility
10 mM in DMSO
Smiles
O=P(N(CCCl)CCCl)(N)O
Molecular Formula
C4H11Cl2N2O2P
Molecular Weight
221.02
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
[1]Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells. Toxicol Appl Pharmacol. 2015 Feb 1; 282 (3) : 252–258.|[2]S Genka, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol. 1990;27 (1) :1-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
SSRN. 2024 Mar 21.|Stem Cell Res Ther. 2024 Apr 5;15 (1) :97.|Climacteric. 2025 Jan 10:1-12.|Int J Nanomedicine. 2025 Aug 22:20:10195-10212.|J Funct Foods. 2025 Jun.|Sci Rep. 2024 Aug 16;14 (1) :19008.|Tufts University. 2025.
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