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Boc-Gln-Ala-Arg-AMC (hydrochloride)

Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2[1][2].

Product Specifications

CAS Number

[201849-55-0]

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/boc-gln-ala-arg-amc-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](CCC(N)=O)NC(OC(C)(C)C)=O)=O)=O)=O)C=C1O2)=CC2=O.Cl

Molecular Formula

C29H43ClN8O8

Molecular Weight

667.15

References & Citations

[1]Mosztbacher D, et al. Measuring digestive protease activation in the mouse pancreas. Pancreatology. 2020 Mar;20 (2) :288-292.|[2]Ko CJ, et al. Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis. Oncogene. 2020 Sep;39 (37) :5950-5963.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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