Α-Conotoxin MI

<strong>α-Conotoxin MI</strong> <strong>Catalog number:</strong> MDP0512 <strong>CAS Number: </strong>124447-81-0 <strong>Sequence: </strong>Gly-Arg-Cys-Cys-His-Pro-Ala-Cys-Gly-Lys-Asn-Tyr-Ser-Cys-NH2 (Disulfide bonds between Cys3-Cys8 and Cys4-Cys14) <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 1493.6 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Guo H, Deng B, Zhao L, Gao Y, Zhang X, Yang C, Zou B, Chen H, Sun M, Wang L, Jiao B. Programmed Aptamer Screening, Characterization, and Rapid Detection for α-Conotoxin MI Toxins (Basel). 2022 Oct 14;14(10):706. 2: Faragó Z, Mirzahosseini A, Horváth D, Pálla T, Horváth P, Perczel A, Noszál B. Solution Structure and Acid-Base Properties of Reduced α-Conotoxin MI Chem Biodivers. 2021 Oct;18(10):e2100464. 3: Zhang M, Yu S, Zhang X, Huang Q, Huang Y, Luo M, Wei Y, Chen W, Chen Z, Zhou X, Dai Q. A new protein-coupled antigen of α-conotoxin MI displays high immunogenicity and can produce antiserum with high detoxification activity Toxicon. 2022 Mar;208:53-61. 4: Luo S, McIntosh JM. Iodo-alpha-conotoxin MI selectively binds the alpha/delta subunit interface of muscle nicotinic acetylcholine receptors Biochemistry. 2004 Jun 1;43(21):6656-62. 5: Gray WR, Rivier JE, Galyean R, Cruz LJ, Olivera BM. Conotoxin MI. Disulfide bonding and conformational states J Biol Chem. 1983 Oct 25;258(20):12247-51. 6: Bren N, Sine SM. Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site J Biol Chem. 2000 Apr 28;275(17):12692-700. 7: Papineni RV, Sanchez JU, Baksi K, Willcockson IU, Pedersen SE. Site-specific charge interactions of alpha-conotoxin MI with the nicotinic acetylcholine receptor J Biol Chem. 2001 Jun 29;276(26):23589-98. 8: Jacobsen RB, DelaCruz RG, Grose JH, McIntosh JM, Yoshikami D, Olivera BM. Critical residues influence the affinity and selectivity of alpha-conotoxin MI for nicotinic acetylcholine receptors Biochemistry. 1999 Oct 5;38(40):13310-5. 9: Gouda H, Yamazaki K, Hasegawa J, Kobayashi Y, Nishiuchi Y, Sakakibara S, Hirono S. Solution structure of alpha-conotoxin MI determined by 1H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water Biochim Biophys Acta. 1997 Dec 5;1343(2):327-34. <a href="https://pubmed.ncbi.nlm.nih.gov/23668937">10: Kapono CA, Thapa P, Cabalteja CC, Guendisch D, Collier AC, Bingham JP. Conotoxin truncation as a post-translational modification to increase the pharmacological diversity within the milked venom of Conus magus Toxicon. 2013 Aug;70:170-8. </a> <br><strong>Products Related to α-Conotoxin MI can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>