NSC 288387

NSC 288387 is a pan-flavivirus MTase inhibitor. NSC 288387 binds to the SAM-binding pocket. NSC 288387 inhibits ZIKV with an IC50 of 0.2 μM. NSC 288387 also inhibits viral replication in cell culture[1].

Product Specifications

CAS Number

[61369-43-5]

UNSPSC

12352005

Target

Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nsc-288387.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C2=CC=CC=C2)N=C3N(CCOC)C4=CC=CC=C4N=C3C1=O

Molecular Formula

C19H16N4O3

Molecular Weight

348.36

References & Citations

[1]Samrat SK, et al. Broad-Spectrum Small-Molecule Inhibitors Targeting the SAM-Binding Site of Flavivirus NS5 Methyltransferase. ACS Infect Dis. 2023 Jul 14;9 (7) :1319-1333.