Cariporide (mesilate)

Cariporide is a Na+/H+ Exchanger 1 (NHE-1) inhibitor. Cariporide inhibits the expression of monocyte endothelial cell adhesion and intercellular adhesion molecule-1 (ICAM-1) mediated by high glucose (HG) by inhibiting the activation of NHE-1[1].

Product Specifications

CAS Number

[159138-81-5]

Product Name Alternative

HOE-642

UNSPSC

12352005

Hazard Statement

H317

Target

Potassium Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cariporide-mesilate.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1.CS(=O)(O)=O

Molecular Formula

C13H21N3O6S2

Molecular Weight

379.45

Precautions

P261-P272-P280-P302+P352-P362+P364-P501

References & Citations

[1]Wang SX, et al. Cariporide inhibits high glucose-mediated adhesion of monocyte-endothelial cell and expression of intercellular adhesion molecule-1. Life Sci. 2006 Aug 29;79 (14) :1399-404.