Emodic acid

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].

Product Specifications

CAS Number

[478-45-5]

Product Name Alternative

NSC624610

UNSPSC

12352005

Target

ERK; JNK; MMP; NF-κB; p38 MAPK; VEGFR

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/emodic-acid.html

Solubility

10 mM in DMSO

Smiles

OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O

Molecular Formula

C15H8O7

Molecular Weight

300.22

References & Citations

[1]Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75 (4) :840-853.