Emodic acid
Product Specifications
UNSPSC Description
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells[1].
Target Antigen
ERK; JNK; MMP; NF-κB; p38 MAPK; VEGFR
Type
Natural Products
Related Pathways
MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/emodic-acid.html
Solubility
10 mM in DMSO
Smiles
OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O
Molecular Weight
300.22
References & Citations
[1]Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-134000/Emodic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-134000/
Clinical Information
No Development Reported
CAS Number
478-45-5
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