(R) -8-Azido-2- (Fmoc-amino) octanoic acid
Selected Variant
HY-131082
Size: 1 Each
(R) -8-Azido-2- (Fmoc-amino) octanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. (R) -8-Azido-2- (Fmoc-amino) octanoic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Product Specifications
CAS Number
1191429-18-1
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-8-azido-2-fmoc-amino-octanoic-acid.html
Solubility
10 mM in DMSO
Smiles
OC([C@@H](CCCCCCN=[N+]=[N-])NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)=O
Molecular Formula
C23H26N4O4
Molecular Weight
422.48
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Price
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Ep-CAM / CD326 (Epithelial Marker) (rEGP40/1110), 0.2mg/mL
Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) (TYRP1/3282), 0.2mg/mL
Estrogen Receptor, alpha (Marker of Estrogen Dependence) (ESR1/1935), CF640R conjugate, 0.1mg/mL
GLG1 (Golgi Complex) (GLG1/970), CF647 conjugate, 0.1mg/mL
