Bis-ANS (dipotassium)

Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS) . Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].

Product Specifications

CAS Number

[65664-81-5]

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bis-ans-dipotassium.html

Purity

99.0

Solubility

DMSO : 30 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC=CC2=C(C3=C4C=CC=C(S(=O)(O[K])=O)C4=C(NC5=CC=CC=C5)C=C3)C=CC(NC6=CC=CC=C6)=C12)(O[K])=O

Molecular Formula

C32H22K2N2O6S2

Molecular Weight

672.85

Precautions

H302, H315, H319, H335

References & Citations

[1]P Horowitz, et al. Bis (1,8-anilinonaphthalenesulfonate) . A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259 (23) :14647-50.|[2]W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)