Pyrantel

Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR) . Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis[1][2].

Product Specifications

CAS Number

[15686-83-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Antibiotic; nAChR; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pyrantel.html

Solubility

10 mM in DMSO

Smiles

CN1CCCN=C1/C=C/C2=CC=CS2

Molecular Formula

C11H14N2S

Molecular Weight

206.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Martin RJ, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34 (9) :1083-90. |[2]Tritten L, et al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5 (12) :e1457.