SAR107375
SAR107375 is a potent and orally active dual thrombin and factor Xa inhibitor, with Ki values of 1 nM and 8 nM for factor Xa and thrombin, respectively[1].
Product Specifications
CAS Number
1184300-63-7
UNSPSC
12352005
Target
Thrombin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sar107375.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(Cl)S1)NC[C@H](NS(=O)(C2=CC=CC(N3C(CCC3)=O)=C2C)=O)C(N4CCN(C)CC4)=O
Molecular Formula
C24H30ClN5O5S2
Molecular Weight
568.11
References & Citations
[1]Jerome Meneyrol, et al. 5-Chlorothiophene-2-carboxylic acid [ (S) -2-[2-methyl-3- (2-oxopyrrolidin-1-yl) benzenesulfonylamino]-3- (4-methylpiperazin-1-yl) -3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor. J Med Chem. 2013 Dec 12;56 (23) :9441-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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