Cytidine-5'-triphosphate-d14 (dilithium)

Cytidine-5'-triphosphate-d14 (Cytidine triphosphate-d14 dilithium; 5'-CTP-d14) dilithium is deuterium labeled Cytidine-5'-triphosphate (HY-125818) . Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP) . Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.

Product Specifications

Product Name Alternative

Cytidine triphosphate-d14 (dilithium) ; 5'-CTP-d14 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

COVID-19-anti-virus

Field of Research

Metabolic Disease

Concentration

100 mM in 19.64 μL Tris HCl/D2O buffer pH=7.5

Purity

98.2

Solubility

10 mM in DMSO

Smiles

O=P(O[2H])(O[Li])OP(OP(OC([2H])([2H])[C@]1([2H])[C@](O[2H])([2H])[C@@](O[2H])([2H])[C@@](N2C(N=C(N([2H])[2H])C([2H])=C2[2H])=O)([2H])O1)(O[2H])=O)(O[Li])=O

Molecular Formula

C9D14Li2N3O14P3

Molecular Weight

509.11

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Heidy Y Narvaez-Ortiz, et al. A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii. Front Cell Infect Microbiol. 2018 Mar 22;8:83.