(S) -JNJ-54166060

(S) -JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist[1].

Product Specifications

CAS Number

[1627900-42-8]

UNSPSC

12352005

Target

P2X Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-jnj-54166060.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC(C(F)(F)F)=C1Cl)N2CCC3=C(N=CN3C4=NC=C(F)C=C4)[C@@H]2C

Molecular Formula

C20H15ClF4N4O

Molecular Weight

438.81

References & Citations

[1]Swanson DM, et al. Identification of (R) - (2-Chloro-3- (trifluoromethyl) phenyl) (1- (5-fluoropyridin-2-yl) -4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5 (4H) -yl) methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. J Med Chem. 2016;59 (18) :8535-8548.