ML358
ML358 is a first in class, potent, and selective inhibitor of the SKN-1 pathway (IC50=0.24 μM) . ML358 sensitizes the model nematode C. elegans to oxidants and anthelmintic. ML358 potentially used as adjuvants to increase the efficacy and useful life of current anthelmintics[1].
Product Specifications
CAS Number
1158607-44-3
UNSPSC
12352005
Target
Insecticide
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ml358.html
Solubility
10 mM in DMSO
Smiles
CCOC1=C(C(Cl)=CC(CNC2CCCC2)=C1)OCC3=CC=C(C=C3)Cl.[H]Cl
Molecular Formula
C21H26Cl3NO2
Molecular Weight
430.80
References & Citations
[1]Peddibhotla, S, et al. Discovery of ML358, a Selective Small Molecule Inhibitor of the SKN-1 Pathway Involved in Drug Detoxification and Resistance in Nematodes. ACS Chemical Biology, 10 (8), 1871–1879.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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