(Z) -KC02

(Z) -KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC) . (Z) -KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z) -KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1].

Product Specifications

CAS Number

[1646795-60-9]

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/z-kc02.html

Concentration

34.80 mM * 100 μL in Ethyl acetate

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(N)CCCC/C=C1C(OC\1CCC2=CC=CC=C2)=O

Molecular Formula

C17H21NO3

Molecular Weight

287.35

References & Citations

[1]Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol. 2015 Feb;11 (2) :164-71.