BMS-639623
Product Specifications
UNSPSC Description
BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma[1].
Target Antigen
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bms-639623.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C2=NN=NN2C)=C1)N[C@H](C)[C@@H](O)CN3C[C@H](CC4=CC=C(F)C=C4)CCC3
Molecular Weight
481.57
References & Citations
[1]Santella JB 3rd, et al. From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis. Bioorg Med Chem Lett. 2008;18(2):576-585.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120629/BMS-639623-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120629/
Clinical Information
No Development Reported
CAS Number
675122-44-8
Curated Selection
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