ML169
Product Specifications
UNSPSC Description
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].
Target Antigen
mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml169.html
Solubility
10 mM in DMSO
Smiles
O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4
Molecular Weight
506.34
References & Citations
[1]Reid PR, et al. Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. Bioorg Med Chem Lett. 2011 May 1;21(9):2697-701.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120576/ML169-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120576/
Clinical Information
No Development Reported
CAS Number
1222878-02-5
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