ML169

ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].

Product Specifications

CAS Number

[1222878-02-5]

Product Name Alternative

VU0405652

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml169.html

Solubility

10 mM in DMSO

Smiles

O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4

Molecular Formula

C21H17BrFN3O4S

Molecular Weight

506.34

References & Citations

[1]Reid PR, et al. Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM) : the development of ML169, an MLPCN probe. Bioorg Med Chem Lett. 2011 May 1;21 (9) :2697-701.