Z-VRPR-FMK

Z-VRPR-FMK is an irreversible MALT1 protein inhibitor. Z-VRPR-FMK inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression[1].

Product Specifications

CAS Number

[1381885-28-4]

UNSPSC

12352005

Target

MALT1

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-vrpr-fmk.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@H](C(CF)=O)CCCNC(N)=N)=O)=O)=O

Molecular Formula

C31H49FN10O6

Molecular Weight

676.78

References & Citations

[1]Jianglong Feng, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12 (6) :1947-1955. |[2]Lorena Fontan, et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell. 2012 Dec 11;22 (6) :812-24.