Recombinant Human Vitamin D-Binding Protein/GC protein (His tag)
Product Specifications
Background
Vitamin D-Binding Protein (DBP) is a member of the ALB/AFP/VDB family. DBP is a secreted protein and contains three albumin domains. The primary structure contains 28 cysteine residues forming multiple disulfide bonds. DBP acts as a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. DBP binds to vitamin D and its plasma metabolites and transports them to target tissues. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
Abbreviation
Vitamin D-Binding; GC
Synonyms
DBP; GC; Gc-Globulin; Group-Specific Component; VDB; Vitamin D-Binding Protein
UniProt
P02774
Accession Number
P02774
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Leu474
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
52.0 kDa
Observed Molecular Weight
57 kDa
Species
Human
Available Sizes
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