VUF10497
VUF10497 is a potent histamine H4 receptor (H4R) inverse agonist with anti-inflammatory activity[1].
Product Specifications
CAS Number
1080623-12-6
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vuf10497.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2=NC(NCC3=CC=CS3)=C4C=C(C=CC4=N2)Cl
Molecular Formula
C18H20ClN5S
Molecular Weight
373.90
References & Citations
[1]Smits RA, et al. Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. J Med Chem. 2008 Dec 25;51 (24) :7855-65.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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