CAY10595

CAY10595 is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki of 10 nM.

Product Specifications

CAS Number

[916047-16-0]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/CAY10595.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2=C1)N(C(C32CC(N(C3=O)CC4=C(C=CC(Cl)=C4)F)=O)=O)CC(O)=O

Molecular Formula

C20H13Cl2FN2O5

Molecular Weight

451.23

References & Citations

[1]Crosignani S, et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J Med Chem. 2008 Apr 10;51 (7) :2227-43.|[2]Maicas N, et al. Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis. Arthritis Rheum. 2012 Jan;64 (1) :130-40.