(aS) -PH-797804
(aS) -PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 nM and 102 nM, respectively. (aS) -PH-797804 has anti-inflammatory activity[1][2].
Product Specifications
CAS Number
1358027-80-1
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/as-ph-797804.html
Solubility
10 mM in DMSO
Smiles
O=C(NC)C1=CC(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C(C)C=C1.[(aS)-PH-797804]
Molecular Formula
C22H19BrF2N2O3
Molecular Weight
477.30
References & Citations
[1]Hope HR, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther. 2009 Dec;331 (3) :882-95.|[2]Selness SR, et al. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2011 Jul 1;21 (13) :4066-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P38α; p38β
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