(aS) -PH-797804

(aS) -PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 nM and 102 nM, respectively. (aS) -PH-797804 has anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[1358027-80-1]

UNSPSC

12352005

Target

P38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/as-ph-797804.html

Solubility

10 mM in DMSO

Smiles

O=C(NC)C1=CC(N2C(C)=CC(OCC3=CC=C(F)C=C3F)=C(Br)C2=O)=C(C)C=C1.[(aS)-PH-797804]

Molecular Formula

C22H19BrF2N2O3

Molecular Weight

477.30

References & Citations

[1]Hope HR, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther. 2009 Dec;331 (3) :882-95.|[2]Selness SR, et al. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett. 2011 Jul 1;21 (13) :4066-71.