(Rac) -BI 703704
(Rac) -BI 703704 is a potent soluble guanylyl cyclase (sGC) activator. (Rac) -BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy[1].
Product Specifications
CAS Number
1423067-48-4
UNSPSC
12352005
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rac-bi-703704.html
Solubility
10 mM in DMSO
Smiles
O=C(C1C2CN(C3=NC(C4=CC(C)=CC=C4OCC5=CC=C(C(N6CCCCC6)=O)C=C5C)=CS3)CC1CC2)O
Molecular Formula
C32H37N3O4S
Molecular Weight
559.72
References & Citations
[1]Yu L, et al. Picrocrocin exhibits growth inhibitory effects against SKMEL- 2 human malignant melanoma cells by targeting JAK/ STAT5 signaling pathway, cell cycle arrest and mitochondrial mediated apoptosis. J BUON. 2018 Jul-Aug;23 (4) :1163-1168.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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