Frizzled 5 Recombinant Protein
Product Specifications
Background
Frizzled-5 (FZD5) is also known as FzE5, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta-catenin pathway. FZD5 interacts with GOPC.
CAS Number
9000-83-3
NCBI Gene ID
7855
Swiss Prot
Q13467
Accession Number
Q13467
Tag
C-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Growth Factors, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH 7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
42.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Frizzled class receptor 5
NCBI Organism
Homo sapiens
Background Reference 01
Hsieh J.C., et al., 1999, Proc. Natl. Acad. Sci. U.S.A. 96:3546-3551.
Background Reference 02
Hao H.X., et al., 2012, Nature 485:195-200.
Other Product Names
FZD5, Frizzled-5, C2orf31, , Fz-5, hFz5, FzE5
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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